Pharmacokinetic studies of phloretin in beagle dogs plasma using LC–MS/MS
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چکیده
منابع مشابه
Subchronic toxicity and plasma pharmacokinetic studies on wogonin, a natural flavonoid, in Beagle dogs.
AIM OF THE STUDY To investigate subchronic toxicity and pharmacokinetic of wogonin using Beagle dog and to provide foundation for clinical applications of this promising anticancer agent. MATERIALS AND METHODS Wogonin was administered via intravenous infusion at dosages of 60, 30 and 15 mg/kg per day for 90 days followed by subchronic toxicity studies including general body parameters, hemato...
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A simple and reproducible HPLC method with spectrophotometric detection was developed for determination of rivastigmine in human plasma. Liquid-liquid extraction of rivastigmine and donepezil (as internal standard) from plasma samples was performed with 1-butanol/n-hexane (2:98 v/v) in alkaline condition followed by back-extraction into diluted acetic acid. Chromatography was carried out using ...
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Organophosphate compounds, which are potent irreversible inhibitors of carboxylic esterases, including cholinesterase, have been extensively used as pesticides throughout the world, and many unfortunate incidents of acute intoxication have been reported (Grob and Harvey, I953; Goldman and Teitel, I958; Healy, 1959; Dinman, I964; Quinby, I964; Crowley and Johns, I966; DePalma, Kwalick, and Zuker...
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ژورنال
عنوان ژورنال: Acta Chromatographica
سال: 2017
ISSN: 2083-5736
DOI: 10.1556/1326.2016.00097